Skylon - currently in development by British company Reaction Engines Ltd. It is hoped that such a craft could take off like a conventional jet powered aircraft, and engage rocket boosters at high altitude to fly into orbit. At a length of 83m, it will be more than 50% greater than the space shuttle.
This thing just looks awesome. It reminds me of the Naboo cruiser.
There is news that my region could be selected as a location for a spaceport from where Skylon could launch! It would be the most awesome thing that could happen if I lived near a spaceport!